Lymphocyte Subset Redistribution in Response to Acute Experimental Stress: Effects of Gender, Ethnicity, Hypertension, and the Sympathetic Nervous System

• Published in: Brain, behavior, and immunity Vol. 9; no. 1; pp. 61 - 69
• Main Authors: Mills, P.J., Berry, C.C., Dimsdale, J.E., Ziegler, M.G., Nelesen, R.A., Kennedy, B.P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-03-1995
• Subjects: Adult; Catecholamines - blood; Female; Humans; Hypertension - complications; Immunity, Cellular; Immunophenotyping; Lymphocyte Subsets - immunology; Lymphocytosis - etiology; Lymphocytosis - immunology; Male; Receptors, Adrenergic, beta-2 - analysis; Smoking - immunology; Stress, Psychological - blood; Stress, Psychological - complications; Stress, Psychological - ethnology; Stress, Psychological - immunology; Stress, Psychological - physiopathology; Sympathetic Nervous System - physiopathology
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1006/brbi.1995.1006

This study examined demographic and adrenergic characteristics associated with enumerative immune responses to acute laboratory stress. Lymphocyte subsets and plasma catecholamines were measured in 110 subjects at rest and following a naturalistic speaking stressor. Lymphocyte β2-adrenergic receptor sensitivity and density were measured at rest. The speaking task caused marked increase in natural killer cells, T-suppressor/cytotoxic cells, total WBC, norepinephrine, and epinephrine and decreases in T-helper cells, B cells, and the T-helper/suppressor ratio. Multiple regression analyses demonstrated that, in general, cellular immune responses were best predicted by a combination of lower basal norepinephrine, higher β2-adrenergic receptor sensitivity, and a greater stress-induced increase in norepinephrine. The findings suggest that traditional epidemiologic characteristics such as gender, ethnicity, and mild hypertension have limited influence on lymphocytosis. Rather, interindividual differences in sympathetic nervous system characteristics play a more prominent underlying role in acute cellular immune system activation.