Release of prostacyclin from cultured human endothelial cells following prolonged exposure to histamine

Histamine is an important pro-inflammatory molecule mediating leukocyte margination, plasma extravasation and vasodilation, but its precise mode of action on vascular endothelium is unclear. We report that histamine is able to induce prolonged release of prostacyclin (PGI2) from human endothelial ce...

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Bibliographic Details
Published in:	British journal of dermatology (1951) Vol. 120; no. 6; p. 757
Main Authors:	Bull, H A, Rustin, M H, Dowd, P M
Format:	Journal Article
Language:	English
Published:	England 01-06-1989
Subjects:	1-Methyl-3-isobutylxanthine - pharmacology Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Bucladesine - pharmacology Cells, Cultured Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Epoprostenol - metabolism Histamine - pharmacology Histamine Antagonists - pharmacology Humans Trifluoperazine - pharmacology
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Summary:	Histamine is an important pro-inflammatory molecule mediating leukocyte margination, plasma extravasation and vasodilation, but its precise mode of action on vascular endothelium is unclear. We report that histamine is able to induce prolonged release of prostacyclin (PGI2) from human endothelial cells via occupancy of the H1 receptor, without an absolute requirement for the presence of histamine or synthesis of new enzyme protein to facilitate continued release of PGI2.
ISSN:	0007-0963
DOI:	10.1111/j.1365-2133.1989.tb01373.x