Parallel increase of plasma apoproteins C-II and C-III in Type 2 diabetic patients

• Published in: Diabetic medicine Vol. 26; no. 7; pp. 736 - 739
• Main Authors: Béliard, S., Nogueira, J. P., Maraninchi, M., Lairon, D., Nicolay, A., Giral, P., Portugal, H., Vialettes, B., Valéro, R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-07-2009; Blackwell
• Subjects: Aged; Apolipoproteins C - blood; apoprotein C-II; apoprotein C-III; Biological and medical sciences; Body Mass Index; Case-Control Studies; Cholesterol, HDL - metabolism; Cholesterol, LDL - metabolism; diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - therapy; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; hypertriglyceridaemia; Hypertriglyceridemia - blood; lipoprotein lipase; Lipoprotein Lipase - metabolism; Male; Medical sciences; Middle Aged; Obesity; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Endocrinopathy; Type 2 diabetes; apoprotein C-II; hypertriglyceridaemia; Lipids; Esterases; Hyperlipoproteinemia; Lipoprotein lipase; Lipoprotein; Enzymopathy; Blood plasma; apoprotein C-III; Dyslipemia; Nutritional status; Human; Obesity; Nutrition; Enzyme; Nutrition disorder; Patient; Metabolic diseases; Increase; Triglyceride; Carboxylic ester hydrolases; Apoproteins; Hypertriglyceridemia; Hydrolases; diabetes; Endocrinology
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2009.02757.x

Aims  To determine plasma levels of apoprotein (apo) C‐II and apoprotein C‐III in Type 2 diabetic patients and to examine the clinical and biological factors that are associated with elevated apoC concentrations.
Methods  We measured apoC‐II and apoC‐III in total plasma and in non‐high‐density lipoprotein fractions by an immunoturbidimetric assay in 88 Caucasian Type 2 diabetic patients and in 138 healthy control subjects.
Results  Plasma levels of both apoC‐II and apoC‐III were increased in Type 2 diabetic patients. The clinical conditions associated with an increase of plasma apoC‐II and apoC‐III were abdominal obesity, body mass index, poor glycaemic control and lack of insulin treatment. However, when multivariate analysis was used, plasma apoCs levels correlated with triglyceride levels only. The apoC‐III/apoC‐II ratio was similar in the Type 2 diabetic and control subjects.
Conclusions  Our study shows the parallel increase of apoC‐II and C‐III in Type 2 diabetic patients. This parallel increase is related to hypertriglyceridaemia only.