The protective effect of intratympanic dexamethasone on cisplatin-induced ototoxicity in guinea pigs

• Published in: Otolaryngology-head and neck surgery Vol. 137; no. 5; pp. 747 - 752
• Main Authors: Daldal, Alper, Odabasi, Onur, Serbetcioglu, Bulent
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Mosby, Inc 01-11-2007; SAGE Publications
• Subjects: Animals; Antineoplastic Agents - adverse effects; Cisplatin - adverse effects; Dexamethasone - administration & dosage; Female; Glucocorticoids - administration & dosage; Guinea Pigs; Hair Cells, Auditory - drug effects; Hearing Loss, Bilateral - chemically induced; Hearing Loss, Bilateral - prevention & control; Injections; Otoacoustic Emissions, Spontaneous - drug effects; Tympanic Membrane
• ISSN: 0194-5998; 1097-6817
• DOI: 10.1016/j.otohns.2007.05.068

The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection as a protection agent against cisplatin-induced ototoxicity.
The four groups of guinea pigs were injected as follows: 1) cisplatin, 2) intratympanic dexamethasone, 3) cisplatin following intratympanic dexamethasone, and 4) cisplatin after intratympanic saline. Before and 3 days following injections, the ototoxic effect was measured with distortion product otoacoustic emissions (DPOAEs).
The DPOAEs amplitudes and signal-to-noise ratio (SNR) values at 1 to 6 kHz frequencies for group 1 animals after injections significantly decreased over those before injections (
P < 0.05). In group 2, there were no significant differences in DPOAE amplitude and SNR values between before and after intratympanic dexamethasone injections (
P > 0.05). Considering group 3, there were also no significant differences in DPOAEs amplitudes and SNR values before and after of dexamethasone and cisplatin injections (
P > 0.05).
Intratympanic dexamethasone injection did not cause any ototoxic effect; in contrast, it might have a significant protective effect after cisplatin injection.