The in vitro adhesion of Candida albicans to buccal epithelial cells (BEC) from diabetic and non-diabetic individuals after in vivo and in vitro application of nystatin

• Published in: Journal of oral pathology & medicine Vol. 26; no. 5; pp. 233 - 236
• Main Authors: Darwazeh, A. M. G., MacFarlane, T. W., Lamey, P.-J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-05-1997; Blackwell
• Subjects: adhesion; Adult; Antifungal Agents - pharmacology; Antifungal Agents - therapeutic use; Biological and medical sciences; Candida albicans; Candida albicans - drug effects; Candida albicans - physiology; Candidiasis, Oral - complications; Candidiasis, Oral - drug therapy; Case-Control Studies; Cell Adhesion - drug effects; Cell Adhesion - physiology; Dentistry; Diabetes Complications; diabetes mellitus; Diabetes Mellitus - microbiology; Diabetes Mellitus - physiopathology; Ent. Stomatology; Epithelial Cells; Epithelium - microbiology; Female; Humans; Male; Medical sciences; Mouth Mucosa - microbiology; nystatin; Nystatin - pharmacology; Nystatin - therapeutic use; Pharmacology. Drug treatments; Endocrinopathy; Candida albicans; Human; Diabetes mellitus; Mucosa; Experimental study; Adhesion; In vitro; Fungi; Oral cavity; In vivo; Antifungal agent; Chemotherapy; Treatment; Biopsy; Epithelial cell; Fungi Imperfecti; Biological effect; Thallophyta; Nystatin
• ISSN: 0904-2512; 1600-0714
• DOI: 10.1111/j.1600-0714.1997.tb01229.x

Buccal epithelial cells (BEC) from 12 patients with diabetes mellitus and 12 age‐and sex‐matched non‐diabetic subjects were tested in vitro for adhesion of Candida albicans following exposure to nystatin both in vitro and in vivo. Adhesion was significantly reduced (P < ss0.002) to cells from both the diabetic and non‐diabetic subjects after in vitro exposure to nystatin. but the reduction in adhesion was variable (5.0–50.7%) in control subjects and 0.5‐4–8.4% in diabetic subjects) and equivalent between the two groups. In vivo exposure to nystatin produced no overall significant reduction in Candida! adhesion to cells from either diabetic or control subjects.