Antidepressant-like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system

• Published in: Fundamental & clinical pharmacology Vol. 27; no. 2; pp. 129 - 137
• Main Authors: Teixeira, Caroline Porto Leite, de Melo, Carla Thiciane Vasconcelos, de Araújo, Fernando Luiz Oliveira, de Carvalho, Allyne Mara Rodrigues, Silva, Maria Izabel Gomes, Barbosa-Filho, José Maria, Macêdo, Danielle Silveira, de Barros Viana, Glauce Socorro, de Sousa, Francisca Cléa Florenço
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-04-2013; Blackwell
• Subjects: Adrenergic Neurons - drug effects; Aniba riparia; Animals; antidepressant-like effect; Antidepressive Agents - pharmacology; Behavior, Animal - drug effects; Behavior, Animal - physiology; Benzamides - pharmacology; Biological and medical sciences; Dopamine Agents - pharmacology; dopaminergic system; Fruit - chemistry; Hindlimb Suspension; Immobility Response, Tonic - drug effects; Lauraceae - chemistry; Male; Medical sciences; Mice; Motor Activity - drug effects; noradrenergic system; Pharmacology. Drug treatments; riparin II; serotonergic system; Serotonin Agents - pharmacology; Swimming; Tyramine - analogs & derivatives; Tyramine - pharmacology; Dopamine; Psychotropic; Rodentia; dopaminergic system; Catecholamine; Vertebrata; Mammalia; Mouse; Animal; Neurotransmitter; Antidepressant agent; riparin II; antidepressant-like effect; serotonergic system; noradrenergic system; Aniba riparia
• ISSN: 0767-3981; 1472-8206
• DOI: 10.1111/j.1472-8206.2011.00973.x

In a previous study conducted by our group, riparin II (ripII) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice. This study investigates a possible antidepressant activity of rip II using two predictive tests for antidepressant activity in rodents: the forced swimming test (FST) and tail suspension test (TST). Additionally, the mechanisms involved in the antidepressant‐like effect in mice were also assessed. Rip II was acute administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that ripII at both tested doses and administration routes produced a significant decrease of immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α1‐adrenoceptor antagonist), SCH23390 (15 μg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p‐chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis), or NAN‐190 (0.5 mg/kg, a serotonin 5‐HT1A receptor antagonist) completely blocked the anti‐immobility effects elicited by riparin II (50 mg/kg, p.o.) in the FST. This study indicates that riparin II produces significant antidepressant‐like activity in the forced swimming and TSTs, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic, and serotonergic systems.