MxA protein - an interferon beta biomarker in primary progressive multiple sclerosis patients

• Published in: European journal of neurology Vol. 15; no. 8; pp. 822 - 826
• Main Authors: Millonig, A., Dressel, A., Bahner, D., Bitsch, A., Bogumil, T., Elitok, E., Kitze, B., Tumani, H., Weber, F., Gneiss, C., Deisenhammer, F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-08-2008
• Subjects: Adjuvants, Immunologic - therapeutic use; Adolescent; Adult; Area Under Curve; biomarker; Biomarkers - blood; clinical trial; Enzyme-Linked Immunosorbent Assay; Female; GTP-Binding Proteins - blood; Humans; Interferon beta; Interferon beta-1b; Interferon-beta - therapeutic use; Male; Middle Aged; Multiple sclerosis; Multiple Sclerosis, Chronic Progressive - blood; Multiple Sclerosis, Chronic Progressive - drug therapy; MxA; Myxovirus Resistance Proteins; neutralizing antibodies; Primary progressive multiple sclerosis
• ISSN: 1351-5101; 1468-1331
• DOI: 10.1111/j.1468-1331.2008.02190.x

Background and purpose:  Interferon beta (IFNβ) preparations have some effect on the progressive phase of multiple sclerosis (MS). This limited effect might be partially because of a certain number of IFNβ non‐responders. Myxovirus resistance protein A (MxA) – a marker of IFNβ bioactivity – was correlated with the clinical response during an uncontrolled trial, investigating the safety of IFNβ‐1b in primary progressive (PPMS) patients.
Methods:  Twenty PPMS were treated with IFNβ‐1b (s.c.) for 1 year. Blood samples were taken before and 1, 2, 3, 6, 9, 12, and 15 months after treatment initiation and MxA protein levels were measured. Patients were clinically evaluated by EDSS and the more sensitive Incapacity Status Scale (ISS) and stratified in a stable and a progressing group.
Results:  Using ISS criteria, 11 patients remained stable and nine patients progressed during treatment. The mean area under the curve of log MxA levels during treatment were significantly higher in stable than in progressing patients (10.87 vs. 5.99; P = 0.002).
Conclusion:  A good biological response to IFNβ might be associated with a better clinical effect of this drug and could be helpful in future clinical studies for early identification of treatment responders.