Improving Effect of the Acute Administration of Dietary Fiber-Enriched Cereals on Blood Glucose Levels and Gut Hormone Secretion

• Published in: Journal of Korean medical science Vol. 31; no. 2; pp. 222 - 230
• Main Authors: Kim, Eun Ky, Oh, Tae Jung, Kim, Lee-Kyung, Cho, Young Min
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01-02-2016; 대한의학회
• Subjects: Adult; Aged; Area Under Curve; Blood Glucose - analysis; Cross-Over Studies; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - diet therapy; Dietary Fiber - therapeutic use; Female; Gastric Inhibitory Polypeptide - blood; Glucagon - blood; Glucagon-Like Peptide 1 - blood; Glycated Hemoglobin A - analysis; Humans; Hyperglycemia - complications; Hyperglycemia - diagnosis; Insulin - blood; Intestines - metabolism; Male; Middle Aged; Original; ROC Curve; 의학일반; Dietary Fiber; Diabetes Mellitus, Type 2; Incretins, Glucagon-like Peptide 1
• ISSN: 1011-8934; 1598-6357
• DOI: 10.3346/jkms.2016.31.2.222

Dietary fiber improves hyperglycemia in patients with type 2 diabetes through its physicochemical properties and possible modulation of gut hormone secretion, such as glucagon-like peptide 1 (GLP-1). We assessed the effect of dietary fiber-enriched cereal flakes (DC) on postprandial hyperglycemia and gut hormone secretion in patients with type 2 diabetes. Thirteen participants ate isocaloric meals based on either DC or conventional cereal flakes (CC) in a crossover design. DC or CC was provided for dinner, night snack on day 1 and breakfast on day 2, followed by a high-fat lunch. On day 2, the levels of plasma glucose, GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and insulin were measured. Compared to CC, DC intake exhibited a lower post-breakfast 2-hours glucose level (198.5±12.8 vs. 245.9±15.2 mg/dL, P<0.05) and a lower incremental peak of glucose from baseline (101.8±9.1 vs. 140.3±14.3 mg/dL, P<0.001). The incremental area under the curve (iAUC) of glucose after breakfast was lower with DC than with CC (P<0.001). However, there were no differences in the plasma insulin, glucagon, GLP-1, and GIP levels. In conclusion, acute administration of DC attenuates postprandial hyperglycemia without any significant change in the representative glucose-regulating hormones in patients with type 2 diabetes (ClinicalTrials.gov. NCT 01997281).