Antibacterial Activities of Transition Metal complexes of Mesocyclic Amidine 1,4-diazacycloheptane (DACH)

• Published in: Open Chemistry Vol. 17; no. 1; pp. 936 - 942
• Main Authors: Rehman, Sadia, Ikram, Muhammad, Subhan, Fazle, Sinnokrot, Mutasem, Khan, Waliullah
• Format: Journal Article
• Language: English
• Published: De Gruyter 01-01-2019
• Subjects: 1,4-diazacycloheptane; bioassay; Coordination complexes; minimum inhibitory concentration
• ISSN: 2391-5420; 2391-5420
• DOI: 10.1515/chem-2019-0108

The titled compound 1,4-diazacycloheptane have vibrational freedom which allows it to coordinate to metal through 1
and 4
positions. Copper (II) and Nickel (II) complexes of DACH were prepared and characterized through UV-Visible, FT-IR, elemental analyses, conductance, and magnetic susceptibilities and compared to the results published in
., 8(3), 528 (1969). The prepared complexes bearing different coordinating or non-coordinating anions were screened against four different pathogenic bacterial strains to study anionic effect on antibacterial activity. The MIC values of all the compounds suggest that [Cu(DACH)
Br
] is almost inactive against the tested microbes except
. Rest of the metal complexes are active at their respective MIC values.