Pathological features of bone marrow transplantation-related toxicity in a mouse

• Published in: Journal of veterinary science (Suwŏn-si, Korea) Vol. 10; no. 4; pp. 361 - 363
• Main Authors: Kim, Y.H., Chungnam National University, Daejeon, Republic of Korea, Ha, C.S., Korea Institute of Toxicology, Daejeon, Republic of Korea, Lee, H.S., Korea Institute of Toxicology, Daejeon, Republic of Korea, Lim, S.H., Korea Institute of Toxicology, Daejeon, Republic of Korea, Moon, K.S., Korea Institute of Toxicology, Daejeon, Republic of Korea, Chung, M.K., Korea Institute of Toxicology, Daejeon, Republic of Korea, Son, H.Y., Chungnam National University, Daejeon, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한수의학회 01-12-2009; The Korean Society of Veterinary Science
• Subjects: Animals; Bone Marrow - pathology; bone marrow transplantation; Bone Marrow Transplantation - adverse effects; Case Report; Cerebellum - pathology; Hemorrhage - pathology; HISTOPATHOLOGIE; HISTOPATHOLOGY; HISTOPATOLOGIA; Liver - pathology; Lung - pathology; Male; Mice; Mice, Inbred C57BL; Myocardium - pathology; PATHOGENESE; PATHOGENESIS; PATOGENESIS; Testis - pathology; Thymus Gland - pathology; TOXICIDAD; TOXICITE; TOXICITY; 수의학; toxicity; histopathology; pathogenesis; bone marrow transplantation
• ISSN: 1229-845X; 1976-555X
• DOI: 10.4142/jvs.2009.10.4.361

In this case report, we present a mock-transduced hone marrow (BM) transplantation in a mouse, which was found moribund and autopsied to evaluate pathogenesis. Macroscopically, red discoloration of systemic organs was observed. Hematological values revealed a decrease in white blood cells, red blood cells, hematocrit, hemoglobin, and platelets, but an increase in reticulocytes. In BM cytology, hematopoietic cell lines were severely depleted. Histopathologically, hemorrhage in the cerebellar parenchyma, hemosiderin deposition and hemorrhage in the heart, necrosis and telangiectasia in liver, pulmonary parenchymal cysts, spermatogenic germ cells necrosis, atrophy and hemorrhage in testis, oligospermia and hemorrhage in the epididymis, and atrophy of BM, thymus and spleen were observed. In conclusion, autoimmune-like complications such as hematological value change, BM dysplasia and systemic hemorrhage appear to be the lethal cause of the mouse transplanted with mock-transduced BM.