Oxaliplatin-Induced Lung Injury with Allergic Reaction

• Published in: Chinese journal of cancer research Vol. 23; no. 3; pp. 232 - 235
• Main Authors: Homma, Tetsuya, Kurokawa, Masatsugu, Yamamoto, Yoshitaka, Matsukura, Satoshi, Ieki, Koushi, Suzuki, Shintaro, Odaka, Miho, Watanabe, Shin, Yamaguchi, Munehiro, Adachi, Mitsuru
• Format: Journal Article
• Language: English
• Published: Heidelberg Chinese Anti-Cancer Association 01-09-2011; Springer-Verlag Berlin Heidelberg
• Subjects: Case Report; Medicine; Medicine & Public Health; 免疫球蛋白E; 嗜酸性粒细胞; 奥沙利铂; 治疗方案; 甲基强的松龙; 肺损伤; 诱导; 过敏性反应; Immunoglobulin E; Oxaliplatin; Drug-induced pneumonia; mFOLFOX6; Drug lymphocyte stimulating test
• ISSN: 1000-9604; 1993-0631
• DOI: 10.1007/s11670-011-0232-y

A 79-year-old man was diagnosed as stage IV colon cancer and treated with a modified FOLFOX6 （mFOLFOX6） regimen.On the 12th cycle,we observed erythema and dyspnea.Radiographs showed ground grass opacities.Blood tests showed elevated levels of eosinophils and immunoglobulin E.We diagnosed this finding as response to drug allergy and administered high-dose methylprednisolone.The treatment was successful and he was discharged.The drug lymphocyte stimulating test against oxaliplatin was positive,indicating a type I and IV allergic reaction due to oxaliplatin.Regimens including oxaliplatin must be carefully monitored and frequent blood tests and chest radiographs are needed.