High frequency stimulation alters motor maps, impairs skilled reaching performance and is accompanied by an upregulation of specific GABA, glutamate and NMDA receptor subunits

• Published in: Neuroscience Vol. 215; pp. 98 - 113
• Main Authors: Henderson, A.K, Pittman, Q.J, Teskey, G.C
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 26-07-2012
• Subjects: Analysis of Variance; Animals; Biomechanical Phenomena; Biophysical Phenomena; Brain Mapping; cortex; Electric Stimulation - adverse effects; Electrodes, Implanted; Forelimb - physiology; high frequency stimulation; Long Evans Hooded rat; Male; Motor Cortex - physiology; Motor Skills Disorders - etiology; Movement - physiology; movement representation; Neurology; plasticity; Protein Subunits - metabolism; Rats; Rats, Long-Evans; Receptors, AMPA - metabolism; Receptors, GABA-A - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; skilled reach training; Statistics, Nonparametric; Time Factors; Up-Regulation - physiology; cortex; ICMS; intracortical microstimulation; High frequency stimulation; rostral forelimb area; long-term depression; LTP; plasticity; RFA; movement representation; low frequency stimulation; skilled reach training; HFS; LFS; Long Evans Hooded rat; LTD; long-term potentiation; high frequency stimulation
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.04.040

Highlights ► High frequency stimulation enlarges motor maps and lowers movement thresholds. ► High frequency stimulation impairs skilled motor learning and alters motor map expression. ► Reach training is associated with altered expression of GABA, glutamate and NMDA receptor subunits.