Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study

• Published in: Wilderness & environmental medicine Vol. 33; no. 4; pp. 379 - 385
• Main Authors: Turgut, Kasım, Yavuz, Erdal, Gülaçtı, Umut, Aydın, İrfan, Sönmez, Cihat, Aktaş, Nurettin, Arslan, Ebru
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Elsevier Inc 01-12-2022; SAGE Publications
• Subjects: Acetaminophen - therapeutic use; Adult; analgesia; Analgesics - therapeutic use; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Double-Blind Method; emergency; Humans; Lidocaine - therapeutic use; Pain - drug therapy; Pain - etiology; Scorpion Stings; visual analog scale; visual analog scale; emergency; analgesia
• ISSN: 1080-6032; 1545-1534
• DOI: 10.1016/j.wem.2022.08.002

After a scorpion sting, patients commonly present to hospitals with pain. Our study sought to compare the analgesic efficacy of IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo in patients reporting pain after presenting with a history of scorpion sting.
This double-blind, randomized, placebo-controlled study was conducted in the emergency department of a tertiary hospital. Adult patients who presented with the complaint of pain after a scorpion sting and did not have systemic findings were randomly assigned to 1 of the following 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo. The visual analog scale scores were measured at the time of presentation to the emergency department and at 30 and 60 min to determine the pain intensity.
The study included 106 patients, of whom 30 were in the paracetamol group, 26 in the dexketoprofen trometamol group, 25 in the topical lidocaine group, and 25 in the placebo group. We did not find a different analgesic effect among the groups in the first 30 min (P=0.185). IV paracetamol, dexketoprofen trometamol, and topical lidocaine did not show different analgesic effects in the first 60 min (P>0.05). IV paracetamol and dexketoprofen trometamol were found to provide a more effective analgesia than the placebo at 60 min (P<0.05). The analgesic effects of topical lidocaine and placebo did not differ (P=0.330).
IV paracetamol and IV dexketoprofen trometamol provided analgesia in the first 60 min, similar to topical lidocaine but superior to placebo.