Novel Functions of Renin Precursors in Homeostasis and Disease

Novel Functions of Renin Precursors in Homeostasis and Disease

Renin progenitors appear early and are found in multiple tissues throughout the embryo. Besides their well known role in blood pressure and fluid homeostasis, renin progenitors participate in tissue morphogenesis, repair, and regeneration, and may integrate immune and endocrine responses. In the bon...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Vol. 31; no. 1; pp. 25 - 33
Main Authors: Gomez, R Ariel, Sequeira-Lopez, Maria Luisa S
Format: Journal Article
Language:English
Published: United States American Physiological Society 01-01-2016
Subjects:
Animals
Blood Pressure - physiology
Bone Marrow - metabolism
Bone Marrow - physiology
Hematopoiesis - physiology
Homeostasis - physiology
Humans
Neoplasms - metabolism
Neoplasms - physiopathology
Renin - metabolism
Renin-Angiotensin System - physiology
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Summary:Renin progenitors appear early and are found in multiple tissues throughout the embryo. Besides their well known role in blood pressure and fluid homeostasis, renin progenitors participate in tissue morphogenesis, repair, and regeneration, and may integrate immune and endocrine responses. In the bone marrow, renin cells offer clues to understand normal and neoplastic hematopoiesis.
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ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00039.2015