Successful early intervention for hyperacute transplant‐associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation

• Published in: Pediatric transplantation Vol. 16; no. 2; pp. E39 - E42
• Main Authors: Jodele, Sonata, Bleesing, Jack J., Mehta, Parinda A., Filipovich, Alexandra H., Laskin, Benjamin L., Goebel, Jens, Pinkard, Susan L., Davies, Stella M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-03-2012
• Subjects: Child, Preschool; Early Medical Intervention; Female; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute - surgery; pediatrics; Postoperative Complications - diagnosis; Postoperative Complications - therapy; TA‐TMA; Thrombotic Microangiopathies - diagnosis; Thrombotic Microangiopathies - etiology; Thrombotic Microangiopathies - therapy; transplant‐associated thrombotic microangiopathy
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1111/j.1399-3046.2010.01408.x

Jodele S, Bleesing JJ, Mehta PA, Filipovich AH, Laskin BL, Goebel J, Pinkard SL, Davies SM. Successful early intervention for hyperacute transplant‐associated thrombotic microangiopathy following pediatric hematopietic stem cell transplantation. 
Pediatr Transplantation 2012: 16: E39–E42. © 2010 John Wiley & Sons A/S.
:  TA‐TMA is a serious complication of hematopoietic stem cell transplantation, presenting as microangiopathic hemolytic anemia with severe renal injury and mortality as high as 60%. Diagnosis and treatment of TA‐TMA is very challenging after HSCT because anemia, thrombocytopenia, hypertension, and renal impairment are multifactorial, leading to delayed recognition and management of this complication. We report a successful outcome following early intervention for hyperacute TA‐TMA after allogeneic HSCT.