A revisit of trisomy 20 mosaicism in prenatal diagnosis--an overview of 103 cases

One hundred and three cases with prenatal diagnosis of trisomy 20 mosaicism through amniocentesis were reviewed. Approximately 90 per cent (90/101) of the cases were associated with grossly normal phenotype. It is likely that, in the majority of cases, cells with trisomy 20 were extraembryonic in or...

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Bibliographic Details
Published in:	Prenatal diagnosis Vol. 11; no. 1; p. 7
Main Authors:	Hsu, L Y, Kaffe, S, Perlis, T E
Format:	Journal Article
Language:	English
Published:	England 01-01-1991
Subjects:	Amniocentesis Child, Preschool Chromosomes, Human, Pair 20 Extraembryonic Membranes - cytology Female Follow-Up Studies Humans Infant Infant, Newborn Male Mosaicism Phenotype Placenta - cytology Pregnancy Trisomy
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Summary:	One hundred and three cases with prenatal diagnosis of trisomy 20 mosaicism through amniocentesis were reviewed. Approximately 90 per cent (90/101) of the cases were associated with grossly normal phenotype. It is likely that, in the majority of cases, cells with trisomy 20 were extraembryonic in origin or largely confined to the placenta. However, in some cases, the cells with trisomy 20 were confined to certain specific fetal organs or tissues such as kidney, skin, etc. Cytogenetic follow-up studies in liveborns should include a culture from urine sediment.
ISSN:	0197-3851
DOI:	10.1002/pd.1970110103