Pyrimidine transport activities in trypanosomes

Parasites of the Trypanosomatidae family are unable to synthesize purines. Instead, they rely on their hosts to supply these necessary compounds. The article by Gudin et al. identifies three transport mechanisms of the equilibrative nucleoside transporter family by which nucleosides and nucleobases...

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Bibliographic Details
Published in:	Trends in parasitology Vol. 23; no. 5; pp. 187 - 189
Main Author:	Bellofatto, Vivian
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-05-2007
Subjects:	Animals Biological Transport Gastroenterology and Hepatology Infectious Disease Mutation Nucleobase Transport Proteins - genetics Nucleobase Transport Proteins - metabolism Nucleoside Transport Proteins - genetics Nucleoside Transport Proteins - metabolism Protozoan Proteins - genetics Protozoan Proteins - metabolism Purines - metabolism Pyrimidines - biosynthesis Pyrimidines - metabolism Trypanosoma Trypanosoma - genetics Trypanosoma - metabolism Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - metabolism Trypanosomatidae
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Summary:	Parasites of the Trypanosomatidae family are unable to synthesize purines. Instead, they rely on their hosts to supply these necessary compounds. The article by Gudin et al. identifies three transport mechanisms of the equilibrative nucleoside transporter family by which nucleosides and nucleobases are transported in this medically important family of organisms. The work by Gudin et al. characterizes the dynamics of these transporters and points to further areas for future genetic and therapeutic experiments.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Commentary-2 ObjectType-Feature-4 ObjectType-Review-1 ObjectType-Article-3
ISSN:	1471-4922 1471-5007
DOI:	10.1016/j.pt.2007.03.003