Caval contribution to flow in the branch pulmonary arteries of fontan patients with a novel application of magnetic resonance presaturation pulse

• Published in: Circulation (New York, N.Y.) Vol. 99; no. 9; pp. 1215 - 1221
• Main Authors: FOGEL, M. A, WEINBERG, P. M, RYCHIK, J, HUBBARD, A, JACOBS, M, SPRAY, T. L, HASELGROVE, J
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 09-03-1999; American Heart Association, Inc
• Subjects: Biological and medical sciences; Blood Flow Velocity; Cardiology. Vascular system; Child, Preschool; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava; Fontan Procedure; Heart; Heart Defects, Congenital - surgery; Humans; Infant; Magnetic Resonance Imaging, Cine - methods; Medical sciences; Phantoms, Imaging; Prospective Studies; Pulmonary Artery - anatomy & histology; Pulmonary Artery - physiology; Reproducibility of Results; Vena Cava, Inferior - anatomy & histology; Vena Cava, Inferior - physiology; Vena Cava, Superior - anatomy & histology; Vena Cava, Superior - physiology; Human; Regional blood flow; Prognosis; Congenital; Cardiovascular disease; Congenital disease; Nuclear magnetic resonance imaging; Fontan operation; Pulmonary artery; Treatment; Surgery; Heart disease; Medical imagery; Technique
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.CIR.99.9.1215

A complete understanding of fluid mechanics in Fontan physiology includes knowledge of the caval contributions to right (RPA) and left (LPA) pulmonary arterial blood flow, total systemic venous return, and relative blood flow to each lung.
Ten Fontan patients underwent cine MRI. Three cine scans of the pulmonary arteries were performed: (1) no presaturation pulse, (2) a presaturation pulse labeling inferior vena cava (IVC) blood (signal void), and (3) a presaturation pulse labeling superior vena cava (SVC) blood. The relative signal decrease is proportional to the amount of blood originating from the labeled vena cava. This method was validated in a phantom. Whereas 60+/-6% of SVC blood flowed into the RPA, 67+/-12% of IVC blood flowed toward the LPA. Of the blood in the LPA and RPA, 48+/-14% and 31+/-17%, respectively, came from the IVC. IVC blood contributed 40+/-16% to total systemic venous return. The distributions of blood to each lung were nearly equal (RPA/LPA blood=0.94+/-11).
In Fontan patients with total cavopulmonary connection, SVC blood is directed toward the RPA and IVC blood is directed toward the LPA. Although the right lung volume is larger than the left, an equal amount of blood flow went to both lungs. LPA blood is composed of equal amounts of IVC and SVC blood because IVC contribution to total systemic venous return is smaller than that of the SVC. This technique and these findings can help to evaluate design changes of the systemic venous pathway to improve Fontan hemodynamics.