Risk factors for periventricular-intraventricular hemorrhage in premature infants

• Published in: Journal of Korean medical science Vol. 25; no. 3; pp. 418 - 424
• Main Authors: Lee, Ju Young, Kim, Han Suk, Jung, Euiseok, Kim, Eun Sun, Shim, Gyu Hong, Lee, Hyun Joo, Lee, Jin A, Choi, Chang Won, Kim, Ee-Kyung, Kim, Beyong Il, Choi, Jung-Hwan
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01-03-2010; 대한의학회
• Subjects: Acidosis - complications; Adult; Birth Weight; Cardiotonic Agents - adverse effects; Case-Control Studies; Cerebral Hemorrhage - etiology; Cerebral Hemorrhage - pathology; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - etiology; Infant, Premature, Diseases - pathology; Male; Odds Ratio; Original; Pregnancy; Retrospective Studies; Risk Factors; 의학일반; Intensive Care, Neonatal; Infant, Premature; Risk Factors; Intracranial Hemorrhages
• ISSN: 1011-8934; 1598-6357
• DOI: 10.3346/jkms.2010.25.3.418

Periventricular-intraventricular hemorrhage (PV-IVH) is a major cause of neurological disabilities in preterm newborns. This study aimed to determine the perinatal factors associated with PV-IVH. We conducted a retrospective case-control study from preterm infants born at < or =34 weeks of gestation and admitted to Neonatal Intensive Care Units of Seoul National University Children's Hospital and Seoul National University Bundang Hospital between June 2003 and December 2007. Neonates with no cranial sonographic data or infants transferred from other centers after three days of age were excluded. Of 1,044 eligible subjects, 59 infants with PV-IVH grade 2, 3, and 4 were allocated to the case group. The control group consisted of 118 infants without PV-IVH who were matched for gestational age and birth weight to each case of PV-IVH. At the multivariate logistic regression model, metabolic acidosis (odds ratio [OR]: 6.94; 95% confidence interval [CI]: 1.12-43.23) and use of inotropes (OR: 3.70; 95% CI: 1.16-11.84) were associated with an increased risk of PV-IVH. Maternal use of antenatal corticosteroids decreases the risk of PV-IVH (OR: 0.36; 95% CI: 0.14-0.92).