Elevated Monocyte to High-density Lipoprotein Ratios as an Inflammation Markers for Schizophrenia Patients

• Published in: Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology Vol. 19; no. 1; pp. 112 - 116
• Main Authors: Sahpolat, Musa, Ayar, Duygu, Ari, Mustafa, Karaman, Mehmet Akif
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean College of Neuropsychopharmacology 28-02-2021; 대한정신약물학회
• Subjects: Original; 정신과학; Schizophrenia; High density lipoprotein; Inflammation; Monocyte
• ISSN: 1738-1088; 2093-4327
• DOI: 10.9758/cpn.2021.19.1.112

Monocyte to high density lipoprotein ratio (MHR) is a new instrument for giving notice inflammation, which plays a main role in schizophrenia. Thus, in this study, our goal was to investigate the possible association between MHR and schizophrenia.
The participants of this study consisted of 75 schizophrenia patients and 74 healthy individuals (control group). The Positive and Negative Syndrome Scale was used to collect data from the patient group. Complete blood count parameters and lipid profile were analyzed in all study participants.
The patients with schizophrenia had higher MHR values (15.04 ± 3.31 in schizophrenia patients and 12.62 ± 2.99 in controls;
= 0.001). Monocyte counts and MHR of the schizophrenia patients were significantly higher than the control group. There was a significant and positive correlation between age, body mass index, severity of disease and MHR.
To our knowledge, this study was the first to demonstrate inflammatory markers such as MHR levels in schizophrenia patients. Both monocyte counts and MHR values in schizophrenia patients were higher than the control group. MHR might be an available and useful inflammatory marker to evaluate inflammation in schizophrenia patients.