Magnet-Guided Temozolomide and Ferucarbotran Loaded Nanoparticles to Enhance Therapeutic Efficacy in Glioma Model

• Published in: Nanomaterials (Basel, Switzerland) Vol. 14; no. 11; p. 939
• Main Authors: Thomas, Reju George, Kim, Subin, Tran, Thi-Anh-Thuy, Kim, Young Hee, Nagareddy, Raveena, Jung, Tae-Young, Kim, Seul Kee, Jeong, Yong Yeon
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27-05-2024; MDPI
• Subjects: Biocompatibility; Blood-brain barrier; Brain; Brain tumors; Cancer; Cell culture; Cell cycle; Chemotherapy; Contrast agents; Contrast media; Cytotoxicity; Drug resistance; Drug therapy; Effectiveness; Fever; Fibroblasts; Glioma; Gliomas; Health aspects; Hemodialysis; Hydration; Hyperthermia; In vivo methods and tests; Life span; Magnetic fields; magnetic guidance; Magnetic resonance imaging; nanoparticle; Nanoparticles; Neuroimaging; Penetration resistance; Polyethylene glycol; Radiation; Reagents; Resveratrol; Surface charge; Synthesis; Temozolomide; theranostics; Toxicity; Tumors; South Korea; Massachusetts; United Kingdom > UK; United States > US; Japan; Germany; glioma; magnetic guidance; nanoparticle; theranostics
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano14110939

The aim of the study was to synthesize liposomal nanoparticles loaded with temozolomide and ferucarbotran (LTF) and to evaluate the theranostic effect of LTF in the glioma model.
We synthesized an LTF that could pass through the Blood Brain Barrier (BBB) and localize in brain tumor tissue with the help of magnet guidance. We examined the chemical characteristics. Cellular uptake and cytotoxicity studies were conducted in vitro. A biodistribution and tumor inhibition study was conduted using an in vivo glioma model.
The particle size and surface charge of LTF show 108 nm and -38 mV, respectively. Additionally, the presence of ferucarbotran significantly increased the contrast agent effect of glioma compared to the control group in MR imaging. Magnet-guided LTF significantly reduced the tumor size compared to control and other groups. Furthermore, compared to the control group, our results demonstrate a significant inhibition in brain tumor size and an increase in lifespan.
These findings suggest that the LTF with magnetic guidance represents a novel approach to address current obstacles, such as BBB penetration of nanoparticles and drug resistance. Magnet-guided LTF is able to enhance therapeutic efficacy in mouse brain glioma.