The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells

We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such potentiation was observed under hypoxic conditions. This pH effect might be relevant both to the therapeutic effectiveness and to the normal tis...

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Bibliographic Details
Published in:	British journal of cancer Vol. 68; no. 4; pp. 681 - 683
Main Authors:	SKARSGARD, L. D, SKWARCHUK, M. W, VINCZAN, A, CHAPLIN, D. J
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-10-1993
Subjects:	Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Cell Hypoxia - physiology Colonic Neoplasms - drug therapy Drug Screening Assays, Antitumor General aspects Humans Hydrogen-Ion Concentration Medical sciences Pharmacology. Drug treatments Tirapazamine Triazines - pharmacology Tumor Cells, Cultured Antineoplastic agent Adenocarcinoma Human Cytotoxicity Malignant tumor Aerobe In vitro Colonic disease Established cell line pH Digestive diseases Intestinal disease Hypoxia Colon
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Summary:	We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such potentiation was observed under hypoxic conditions. This pH effect might be relevant both to the therapeutic effectiveness and to the normal tissue toxicity of this new agent.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.1993.409