High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease

High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease

Central Illustration Schematic of HDL Nanoparticles Used for PET Imaging High-density lipoprotein (HDL) nanoparticles were synthesized containing the positron emission tomography (PET) isotope89 Zr and injected into atherosclerosis-bearing animals. Three animal models of atherosclerosis, mice, rabbi...

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Bibliographic Details
Published in:JACC. Basic to translational science Vol. 2; no. 1; pp. 98 - 100
Main Authors: Leeper, Nicholas J., MD, Park, Seung-min, PhD, Smith, Bryan Ronain, PhD
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-02-2017
Elsevier
Subjects:
atherosclerosis
Cardiovascular
HDL
imaging
Journal Watch
macrophages/monocytes
nanoparticles
atherosclerosis
HDL
nanoparticles
macrophages/monocytes
imaging
Online Access:Get full text
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Summary:Central Illustration Schematic of HDL Nanoparticles Used for PET Imaging High-density lipoprotein (HDL) nanoparticles were synthesized containing the positron emission tomography (PET) isotope89 Zr and injected into atherosclerosis-bearing animals. Three animal models of atherosclerosis, mice, rabbits, and pigs, were tested. HDL nanoparticles entered plaque macrophages and monocytes, demonstrating delivery to atherosclerotic plaques in animal arteries as measured by PET molecular imaging.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2452-302X
2452-302X
DOI:10.1016/j.jacbts.2017.01.005