Analysis of major histocompatibility complex and CTLA-4 alleles in Brazilian patients with primary biliary cirrhosis

Background and Aims:  Predisposition to primary biliary cirrhosis (PBC) has been classically linked to HLA‐DRB1 locus. However, the presence of the HLA‐DRB1*08 antigen has been reported in less than one‐third of PBC patients from Northern Europe and Japan. Recently, polymorphisms in the tumor necros...

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Published in:Journal of gastroenterology and hepatology Vol. 18; no. 9; pp. 1061 - 1066
Main Authors: BITTENCOURT, PAULO LISBOA, PALÁCIOS, SELMA ALIOTTI, FARIAS, ALBERTO QUEIROZ, ABRANTES-LEMOS, CLARICE PIRES, CANÇADO, EDUARDO LUIZ RACHID, CARRILHO, FLAIR JOSÉ, LAUDANNA, ANTONIO ATÍLIO, KALIL, JORGE, GOLDBERG, ANNA C
Format: Journal Article
Language:English
Published: Melbourne, Australia Blackwell Science Pty 01-09-2003
Blackwell Science
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Summary:Background and Aims:  Predisposition to primary biliary cirrhosis (PBC) has been classically linked to HLA‐DRB1 locus. However, the presence of the HLA‐DRB1*08 antigen has been reported in less than one‐third of PBC patients from Northern Europe and Japan. Recently, polymorphisms in the tumor necrosis factor alpha (TNFA) gene promoter at position −308 and in exon 1 of the cytotoxic T lymphocyte antigen‐4 (CTLA‐4) gene at position 49 have been associated with susceptibility to PBC in Caucasians. In addition, the presence of HLA‐DRB1*08 and the TNFA*1 allele was also linked to progression to end‐stage liver disease. The aims of the present study were to investigate the frequencies of HLA‐DR and DQ antigens and TNFA and CTLA‐4 alleles in PBC patients from a different genetic background, as well as to assess the role of TNFA alleles and HLA‐DR antigens in disease progression. Methods:  Determination of HLA‐DRB1, DQB1, TNFA and CTLA‐4 alleles was performed in patients with PBC and healthy controls using polymerase chain reaction‐based techniques. Results:  Frequencies of HLA‐DR and DQ antigens were similar in PBC patients and healthy controls. Accordingly, no association between TNFA and CTLA‐4 alleles was observed in PBC patients. The histological stage at admission of patients with PBC also showed no correlation with HLA antigens and TNFA and CTLA‐4 alleles. Conclusions:  Susceptibility to PBC in Brazil is not associated with HLA‐DR and DQ antigens and CTLA‐4 genotypes. TNFA alleles were not shown to influence disease progression.
Bibliography:ark:/67375/WNG-RVZZJGZQ-1
istex:35E289884C2801DADCEE03E2EDF200716315FF8B
ArticleID:JGH3091
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0815-9319
1440-1746
DOI:10.1046/j.1440-1746.2003.03091.x