The relationship of fetuin-A and lactoferrin with bone mass in elderly women

• Published in: Osteoporosis international Vol. 22; no. 7; pp. 2159 - 2164
• Main Authors: Chailurkit, L., Kruavit, A., Rajatanavin, R., Ongphiphadhanakul, B.
• Format: Journal Article
• Language: English
• Published: London Springer-Verlag 01-07-2011; Springer; Springer Nature B.V
• Subjects: Absorptiometry, Photon; Aged; Aged, 80 and over; alpha-2-HS-Glycoprotein - metabolism; Biological and medical sciences; Bone density; Bone Density - physiology; Bone Resorption - blood; Collagen Type I - blood; Diseases of the osteoarticular system; Endocrinology; Female; Femur Neck - diagnostic imaging; Humans; Investigative techniques, diagnostic techniques (general aspects); Lactoferrin - blood; Lumbar Vertebrae - diagnostic imaging; Medical sciences; Medicine; Medicine & Public Health; Older people; Original Article; Orthopedics; Osteoarticular system. Muscles; Osteoporosis. Osteomalacia. Paget disease; Parathyroid Hormone - blood; Peptide Fragments - blood; Peptides - blood; Procollagen - blood; Proteins; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Rheumatology; Women; Fetuin-A; Lactoferrin; Bone mineral density; Human; Osteoporosis; Bone mass; Diseases of the osteoarticular system; Woman; Elderly
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-010-1439-3

Summary
The relationships of fetuin-A and lactoferrin to bone-related phenotypes were investigated in elderly women. Fetuin-A was associated not only with bone mineral density (BMD) but also with bone resorption marker suggesting an influence of fetuin-A on osteoclasts.
Introduction
The aim of this study is to investigate the relationship of bone-related phenotypes in elderly women with circulating fetuin-A and lactoferrin.
Methods
Eighty-two elderly women were studied. Serum fetuin-A, lactoferrin, C-terminal telopeptide of type I collagen (CTx), total procollagen type 1 amino-terminal propeptide, and plasma intact parathyroid hormone (PTH) were analyzed. BMD of the lumbar spine at L2–4 and at the femoral neck was measured.
Results
Serum fetuin-A was significantly associated with L2–4 BMD (
r
 = 0.23,
P
 < 0.05). After controlling for age and body weight, the association remained statistically significant. There was a significant association between serum fetuin-A and serum CTx (
r
 = −0.37,
P
 < 0.001). The association between fetuin-A and L2–4 BMD no longer existed after controlling for serum CTx. There were positive associations of circulating lactoferrin with plasma PTH (
r
 = 0.24,
P
 < 0.05) and serum CTx (
r
 = 0.26,
P
 < 0.05). No association between serum lactoferrin and BMD at the lumbar spine or femoral neck was detected.
Conclusions
Circulating fetuin-A is related to bone mass and bone resorption markers in elderly women. Lactoferrin, in contrast, is associated only with bone resorption markers.