Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations

• Published in: Frontiers in pharmacology Vol. 13; p. 881617
• Main Authors: Souza, José Diogo S, Fassoni-Ribeiro, Maíra, Batista, Rayssa Miranda, Ushirohira, Juliana Mayumi, Zuardi, Antonio W, Guimarães, Francisco S, Campos, Alline C, Osório, Flávia de Lima, Elias, Daniel, Souza, Cacilda S, Fassoni, AndRea A, Hallak, Jaime E C, Crippa, José Alexandre S
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19-05-2022
• Subjects: cannabidiol; case report; case series; drug interaction; Pharmacology; side effects; skin rash; cannabidiol; skin rash; case report; side effects; case series; drug interaction
• ISSN: 1663-9812; 1663-9812
• DOI: 10.3389/fphar.2022.881617

Cannabidiol (CBD) is a non-psychotomimetic constituent of the
plant, with potential therapeutic properties for many physical and neuropsychiatric conditions. Isolated CBD has been suggested to have favorable safety and tolerability. Although CBD-related rash is described, few case reports are well documented in the literature, and usually, CBD was used concomitantly with other medications. Thus, we report four women who presented a skin rash after ongoing CBD use. Other causes of these skin rashes were ruled out after conducting an extensive viral and serological detection panel, and three patients had their lesions biopsied. Two patients were re-exposed to the vehicle (MCT) without developing a new skin rash. Therefore, clinicians must be aware of this potential adverse effect of CBD use.