Increased serum cathepsin K in patients with coronary artery disease

• Published in: Yonsei medical journal Vol. 55; no. 4; pp. 912 - 919
• Main Authors: Li, Xiang, Li, Yuzi, Jin, Jiyong, Jin, Dehao, Cui, Lan, Li, Xiangshan, Rei, Yanna, Jiang, Haiying, Zhao, Guangxian, Yang, Guang, Zhu, Enbo, Nan, Yongshan, Cheng, Xianwu
• Format: Journal Article
• Language: English
• Published: Korea (South) Yonsei University College of Medicine 01-07-2014; 연세대학교의과대학
• Subjects: Aged; Biomarkers - blood; C-Reactive Protein - metabolism; Cathepsin K - blood; Coronary Artery Disease - blood; Coronary Artery Disease - metabolism; Female; Humans; Male; Middle Aged; Original; 의학일반; coronary artery disease; myocardial ischemia; Cathepsin K; biomarker; high sensitive C-reactive protein
• ISSN: 0513-5796; 1976-2437
• DOI: 10.3349/ymj.2014.55.4.912

Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD).
Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 age-matched subjects served as controls.
The subjects' serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher serum cathepsin K levels compared to the controls (130.8±25.5 ng/mL vs. 86.9±25.5 ng/mL, p<0.001), and the patients with acute coronary syndrome had significantly higher serum cathepsin K levels compared to those with stable angina pectoris (137.1±26.9 ng/mL vs. 102.6±12.9 ng/mL, p<0.001). A linear regression analysis showed that overall, the cathepsin K levels were inversely correlated with the high-density lipoprotein levels (r=-0.29, p<0.01) and positively with hs-CRP levels (r=0.32, p<0.01). Multiple logistic regression analyses shows that cathepsin K levels were independent predictors of CAD (odds ratio, 1.76; 95% confidence interval, 1.12 to 1.56; p<0.01).
These data indicated that elevated levels of cathepsin K are closely associated with the presence of CAD and that circulating cathepsin K serves a useful biomarker for CAD.