Sensory Symptoms without Structural Pathology in Patients with Gluten Sensitivity

• Published in: Nutrients Vol. 16; no. 8; p. 1209
• Main Authors: Hadjivassiliou, Marios, Trott, Nick, Hoggard, Nigel, Sanders, David S
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19-04-2024; MDPI
• Subjects: Adult; Aged; Antibodies; Ataxia; Biopsy; Brief Report; Celiac disease; Celiac Disease - complications; Celiac Disease - diet therapy; coeliac disease; Diet, Gluten-Free; Female; Gluten; gluten sensitivity; gluten-free diet; Glutens - adverse effects; Humans; Male; Middle Aged; neurological manifestations; Neurology; Pandemics; Pathology; Patients; Sensation Disorders - etiology; sensory symptoms; Serology; Teaching hospitals; Young Adult; coeliac disease; gluten sensitivity; gluten-free diet; neurological manifestations; sensory symptoms
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16081209

We report on a group of patients with gluten sensitivity with and without coeliac disease presenting with unexplained sensory symptoms in the absence of structural pathology.
The patients were selected from the gluten neurology clinic based at the Royal Hallamshire Hospital, Sheffield, UK, on the basis of sensory symptoms but normal neuroaxis imaging and peripheral nerve evaluation.
A total of 30 patients were identified with a mean age at presentation of 47 years. The prevalence of enteropathy was 78%. The sensory disturbance was characterised by tingling at 50%, numbness at 27%, pain at 20%, burning at 13% and "buzzing" feeling at 7%. The distribution of the sensory symptoms included hands and feet in 27% of the patients, torso in 27%, legs only in 23%, face in 17% and arms only in 10%. For five patients, the sensory disturbance was migratory and affected different parts of the body at any given time. After the introduction of a gluten-free diet, 77% of patients noted significant improvement in their sensory symptoms. In one-third of the patients, there was a complete resolution of the sensory symptoms.
Unexplained sensory symptoms can be seen in patients with gluten sensitivity and respond to strict adherence to a gluten-free diet.