Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: A proof of concept study

• Published in: Journal of science and medicine in sport Vol. 22; no. 7; pp. 808 - 813
• Main Authors: Paing, Aye C., McMillan, Kathryn A., Kirk, Alison F., Collier, Andrew, Hewitt, Allan, Chastin, Sebastien F.M.
• Format: Journal Article
• Language: English
• Published: Australia Elsevier Ltd 01-07-2019; Elsevier Limited
• Subjects: Alcohol; Body mass index; Carbohydrates; Diabetes; Diabetes mellitus; Diet; Energy; Exercise; Glucose; Insulin resistance; Laboratories; Meals; Proteins; Researchers; Sedentary behavior; Sedentary lifestyle; Studies; Walking; United Kingdom > UK; Sedentary lifestyle; Exercise; Glucose; Diabetes mellitus
• ISSN: 1440-2440; 1878-1861
• DOI: 10.1016/j.jsams.2019.01.017

This study aimed to investigate dose-response between frequency of breaks in sedentary time and glucose control.
Randomised three-treatment, two-period balanced incomplete block trial.
Twelve adults with type 2 diabetes (age, 60±11years; body mass index, 30.2±4.7kg/m2) participated in two of the following treatment conditions: sitting for 7h interrupted by 3min light-intensity walking breaks every (1) 60min (Condition 1), (2) 30min (Condition 2), and (3) 15min (Condition 3). Postprandial glucose incremental area under the curves (iAUCs) and 21-h glucose total area under the curve (AUC) were measured using continuous glucose monitoring. Standardised meals were provided.
Compared with Condition 1 (6.7±0.8mmolL−1×3.5h−1), post-breakfast glucose iAUC was reduced for Condition 3 (3.5±0.9 mmolL−1×3.5h−1, p˂0.04). Post-lunch glucose iAUC was lower in Condition 3 (1.3±0.9mmolL−1×3.5h−1, p˂0.03) and Condition 2 (2.1±0.7mmolL−1×3.5h−1, p˂0.05) relative to Condition 1 (4.6±0.8mmolL−1×3.5h−1). Condition 3 (1.0±0.7mmolL−1×3.5h−1, p=0.02) and Condition 2 (1.6±0.6mmolL−1×3.5h−1, p˂0.04) attenuated post-dinner glucose iAUC compared with Condition 1 (4.0±0.7mmolL−1×3.5h−1). Cumulative 10.5-h postprandial glucose iAUC was lower in Condition 3 than Condition 1 (p=0.02). Condition 3 reduced 21-h glucose AUC compared with Condition 1 (p<0.001) and Condition 2 (p=0.002). However, post-breakfast glucose iAUC, cumulative 10.5-h postprandial glucose iAUC and 21-h glucose AUC were not different between Condition 2 and Condition 1 (p˃0.05).
There could be dose-response between frequency of breaks in sedentary time and glucose. Interrupting sedentary time every 15min could produce better glucose control.