Effectiveness of Hypericum perforatum Extract in the Treatment of Corrosive Esophageal Burns

• Published in: Journal of investigative surgery Vol. 35; no. 3; pp. 647 - 652
• Main Authors: Sümeli, Rezzan, Cömert, Hatice Sonay Yalçın, Sarıhan, Haluk, İmamoğlu, Mustafa, Saygın, İsmail
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01-03-2022; Taylor & Francis Group
• Subjects: Animals; Caustics - toxicity; Corrosive esophagus; esophageal strictures; fibrosis; Hypericum; Hypericum perforatum; inflammation; necrosis; Plant Extracts - therapeutic use; Plant Oils; Rats; Rats, Sprague-Dawley; Hypericum perforatum; esophageal strictures; fibrosis; Corrosive esophagus; inflammation; necrosis
• ISSN: 0894-1939; 1521-0553
• DOI: 10.1080/08941939.2021.1921083

The purpose of our study is to determine the effectiveness of "Hypericum perforatum" extract in corrosive esophageal burns and to shed light on the search for new treatments.
A total of 32 Sprague Dawley rats were separated into 4 groups. A standard esophageal burn model was created. Group 1 was identified as the sham group. Group 2 was burned and no treatment was performed afterward. Group 3 was burned and then 2 cc/day H. perforatum extract was given for 21 days. Group 4 was not applied any process and 2 cc/day H. perforatum extract was given for 21 days. The rats were sacrificed and biopsy specimens were taken for histopathological examination for the presence of inflammation, fibrosis, and necrosis.
There was a significant difference between groups in terms of inflammation, fibrosis, and necrosis. Furthermore, in the bilateral comparisons between the groups, there was a meaningful difference in terms of inflammation and fibrosis between Group 2 and Group 3. However, there was no meaningful difference between the same groups in terms of necrosis.
H. perforatum extract may be effective on inflammation, fibrosis, and necrosis in corrosive esophageal burns.