Omalizumab may decrease the thickness of the reticular basement membrane and fibronectin deposit in the bronchial mucosa of severe allergic asthmatics

• Published in: The Journal of asthma Vol. 57; no. 5; pp. 468 - 477
• Main Authors: Zastrzeżyńska, Weronika, Przybyszowski, Marek, Bazan-Socha, Stanisława, Gawlewicz-Mroczka, Agnieszka, Sadowski, Piotr, Okoń, Krzysztof, Jakieła, Bogdan, Plutecka, Hanna, Ćmiel, Adam, Sładek, Krzysztof, Musiał, Jacek, Soja, Jerzy
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03-05-2020
• Subjects: Adult; airway remodeling; Airway Remodeling - drug effects; Anti-Asthmatic Agents - therapeutic use; Asthma; Asthma - drug therapy; Asthma - metabolism; Asthma - pathology; Asthma - physiopathology; Basement Membrane - drug effects; Basement Membrane - metabolism; Basement Membrane - pathology; Bronchi - drug effects; Bronchi - metabolism; Bronchi - pathology; Female; fibronectin; Fibronectins - metabolism; Humans; IgE; Immunoglobulin E - blood; Male; Middle Aged; omalizumab; Omalizumab - therapeutic use; Respiratory Mucosa - drug effects; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Spirometry; Treatment Outcome; omalizumab; fibronectin; IgE; airway remodeling; Asthma
• ISSN: 0277-0903; 1532-4303
• DOI: 10.1080/02770903.2019.1585872

Introduction: Immunoglobulin E is an important modulator of the inflammatory reaction in allergic asthma. It also contributes to airway remodeling in the course of the disease. The authors evaluated airway structural changes in severe allergic asthma during the omalizumab therapy. Patients and methods: The study included 13 patients with severe allergic asthma treated with omalizumab for at least one year. In each patient clinical, laboratory, and spirometry parameters were evaluated before and after the treatment. In addition, bronchoscopy with bronchial mucosa biopsy and bronchoalveolar lavage was performed. The basal lamina thickness, inflammatory cell infiltration, fibronectin, as well as type I and III collagen accumulation were assessed in bronchial mucosa specimens, together with the assessment of bronchoalveolar lavage cellularity. Results: The omalizumab therapy led to a decrease in the basal lamina thickness (p = 0.002), and to a reduction in fibronectin (p = 0.02), but not collagen deposits in the bronchial mucosa. The decrease in fibronectin accumulation was associated with an improvement in asthma control and quality of life (p = 0.01, both), and a diminished dose of systemic corticosteroids (p = 0.001). It was also associated with a tendency towards reduction of the eosinophil count in the peripheral blood, bronchoalveolar lavage fluid, and bronchial mucosa specimens. Conclusion: Our study has shown that omalizumab, effective in the treatment of severe allergic asthma, may also decrease unfavorable structural airway changes in allergic asthmatics, at least with respect to the fibronectin deposit and an increased thickness of the basal lamina. However, more extensive observational studies are needed to verify the above hypothesis.