Anticoagulant, Antiherpetic and Antibacterial Activities of Sulphated Polysaccharide from Indian Medicinal Plant Tridax procumbens L. (Asteraceae)

• Published in: Applied biochemistry and biotechnology Vol. 165; no. 3-4; pp. 902 - 912
• Main Authors: Naqash, Shabeena Yousuf, Nazeer, R. A.
• Format: Journal Article
• Language: English
• Published: New York Humana Press Inc 01-10-2011; Springer; Springer Nature B.V
• Subjects: Animals; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Anticoagulants; Anticoagulants - isolation & purification; Anticoagulants - pharmacology; Anticoagulants - therapeutic use; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Asteraceae; Asteraceae - chemistry; Bacteria; Biochemistry; Biological and medical sciences; Biotechnology; Cercopithecus aethiops; Chemistry; Chemistry and Materials Science; Chemistry, Pharmaceutical - methods; Chondroitin Sulfates - pharmacology; Flowers & plants; Fundamental and applied biological sciences. Psychology; Hemorrhage - drug therapy; Heparin - pharmacology; Herpes Simplex - drug therapy; Herpes Simplex - virology; Herpes simplex virus 1; Herpesvirus 1, Human - drug effects; Inhibitory Concentration 50; Medicinal plants; Partial Thromboplastin Time; Phytotherapy; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plants, Medicinal - chemistry; Polysaccharides - isolation & purification; Polysaccharides - pharmacology; Polysaccharides - therapeutic use; Sardinops; Sulfur content; Tridax procumbens; Vero Cells; Vibrio alginolyticus; Vibrio alginolyticus - drug effects; Vibrio harveyi; Vibrio Infections - drug therapy; Vibrio Infections - microbiology; Sulphated polysaccharide; aPTT; HSV-I; Dicotyledones; Angiospermae; Tridax procumbens; Spermatophyta; Anticoagulant; Antibacterial agent; Compositae; Polysaccharide; Medicinal plant
• ISSN: 0273-2289; 1559-0291
• DOI: 10.1007/s12010-011-9307-y

The sulphated polysaccharide from the widespread
Tridax procumbens
plant was studied for the anticoagulant, antiherpetic and antibacterial activity. The anticoagulant activity was determined by the activated partial thromboplastin time assay. The sulphated polysaccharide from
T. procumbens
represented potent anticoagulant reaching the efficacy to heparin and chondroitin sulphate. Moreover, the sulphated polysaccharide extracted from
T. procumbens
was found non-toxic on Vero cell lines up to the concentration of 200 μg/ml. Sulphated polysaccharide exhibited detectable antiviral effect towards HSV-1 with IC
50
value 100–150 μg/ml. Furthermore, sulphated polysaccharide from
T. procumbens
was highly inhibitory against the bacterial strains
Vibrio alginolyticus
and
Vibrio harveyi
isolated from oil sardine.