Towards a molecular approach to gastric cancer management

• Published in: Internal medicine journal Vol. 31; no. 5; pp. 296 - 303
• Main Authors: Boussioutas, A., Taupin, D.
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01-07-2001; Blackwell Science
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Biomarkers, Tumor - blood; cDNA microarray; Combined Modality Therapy; Digestive System Surgical Procedures; expression analysis; gastric cancer; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation, Neoplastic; Humans; Medical sciences; Oligonucleotide Array Sequence Analysis; Stomach Neoplasms - blood; Stomach Neoplasms - epidemiology; Stomach Neoplasms - genetics; Stomach Neoplasms - therapy; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Survival Analysis; Tumors; tumour array; tumour marker; Human; Stomach; Treatment; Pathogenesis; Digestive diseases; Tumoral marker; Review; Malignant tumor
• ISSN: 1444-0903; 1445-5994
• DOI: 10.1046/j.1445-5994.2001.00057.x

Gastric cancer is a leading cause of cancer death worldwide. Most patients with gastric cancer present with locally advanced and incurable disease, and overall survival is poor. Considerable research efforts towards the epidemiology and pathogenesis of gastric cancer have not been translated into treatment success. We discuss current concepts of the pathogenesis of gastric cancer and how recent research advances, in particular global gene expression strategies, may improve this understanding, and suggest a framework wherein these approaches may be used. (Intern Med J 2001; 31: 296–303)