Effect of propiverine hydrochloride on the function of the bladder in dogs

• Published in: Nihon yakurigaku zasshi Vol. 93; no. 2; p. 55
• Main Authors: Kaneko, S, Haruno, A, Suzuki, N, Kitazato, K, Yamazaki, Y, Nagai, M, Iriki, M, Tsuchiya, K, Kosaka, M
• Format: Journal Article
• Language: Japanese
• Published: Japan 1989
• Subjects: Animals; Benzilates - pharmacology; Benzilates - therapeutic use; Dogs; Dose-Response Relationship, Drug; Female; Flavoxate - pharmacology; Male; Muscle Contraction - drug effects; Muscle, Smooth - drug effects; Parasympatholytics - pharmacology; Parasympatholytics - therapeutic use; Polyuria - drug therapy; Urinary Bladder - drug effects; Urination - drug effects
• ISSN: 0015-5691
• DOI: 10.1254/fpj.93.55

Propiverine hydrochloride (P-4) is a new derivative of benzilic acid. The effect of P-4 on the function of the bladder in anesthetized dogs was studied in comparison with flavoxate, which is clinically used for the treatment of pollakiuria. P-4 (4 mg/kg, i.v.) caused a significant increase in maximum vesical volume (Vmax), which was estimated by a cystometrogram. A similar effect was also observed following intravenous administration of verapamil (1 mg/kg), while flavoxate (4 mg/kg, i.v.) caused no significant changes in Vmax. P-4 significantly decreased the frequency of rhythmic bladder contractions at doses higher than 1 mg/kg, i.v., whereas flavoxate first revealed a significant decrease at 4 mg/kg, i.v. Thus the inhibitory effect of P-4 on the micturition movements of the bladder is more potent than that of flavoxate. These findings indicate that P-4 is a useful drug for the treatment of pollakiuria.