Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications

Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications

Intracellular micromanipulation assisted by robotic systems has valuable applications in biomedical research, such as genetic diagnosis and genome-editing tasks. However, current studies suffer from a low success rate and a large operation damage because of insufficient information on the operation...

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Bibliographic Details
Published in:Applied sciences Vol. 10; no. 20; p. 7308
Main Authors: Gao, Wendi, Zhao, Libo, Jiang, Zhuangde, Sun, Dong
Format: Journal Article
Language:English
Published: Basel MDPI AG 15-10-2020
Subjects:
Biological computing
biological imaging
Biomedical engineering
computational imaging
Computer applications
Diagnostic imaging
Genetic screening
Genomes
Intracellular
intracellular micromanipulation
Localization
Medical research
Methods
Micromanipulation
Microscopes
Tomography
China
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Summary:Intracellular micromanipulation assisted by robotic systems has valuable applications in biomedical research, such as genetic diagnosis and genome-editing tasks. However, current studies suffer from a low success rate and a large operation damage because of insufficient information on the operation information of targeted specimens. The complexity of the intracellular environment causes difficulties in visualizing manipulation tools and specimens. This review summarizes and analyzes the current development of advanced biological imaging sampling and computational processing methods in intracellular micromanipulation applications. It also discusses the related limitations and future extension, providing an important reference about this field.
ISSN:2076-3417
2076-3417
DOI:10.3390/app10207308