Anticonvulsant activity of reaction products of 5,5-diphenylhydantoin with substituted methylene bromides

• Published in: Archiv der Pharmazie (Weinheim) Vol. 334; no. 11; pp. 366 - 368
• Main Author: Usifoh, Cyril O.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag GmbH 01-12-2001; WILEY‐VCH Verlag GmbH; Wiley-VCH
• Subjects: Animals; Anticonvulsants; Anticonvulsants - chemical synthesis; Anticonvulsants - pharmacology; Anticonvulsants - toxicity; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Dose-Response Relationship, Drug; Electroshock; Hydantoins; Hydrocarbons, Brominated - chemistry; Injections, Intraperitoneal; Medical sciences; Methylene bromides; Mice; Neuropharmacology; Pharmacology. Drug treatments; Phenytoin - chemical synthesis; Phenytoin - pharmacology; Phenytoin - toxicity; Rats; Seizures - prevention & control; Imidazole derivatives; Intraperitoneal administration; Nitrile; Rat; Nitrogen heterocycle; Rodentia; Oral administration; Anticonvulsant; Hydantoins; Biological activity; Vertebrata; Mammalia; Mouse; Animal; Chemical synthesis; Ethylenic compound
• ISSN: 0365-6233; 1521-4184
• DOI: 10.1002/1521-4184(200112)334:11<366::AID-ARDP366>3.0.CO;2-Q

Some derivatives of 5,5‐diphenylhydantoin (phenytoin) were synthesized by the alkylation of phenytoin with substituted methylene bromides. The hydantoins were evaluated for possible anticonvulsant activity in the maximal electroshock (MES)‐ and subcutaneous pentylenetetrazole (ScMet)‐induced seizures and for neurotoxicity in the rotorod test in mice and rats.