Apolipoprotein A-IV-2 allele: Association of its worldwide distribution with adult persistence of lactase and speculation on its function and origin

Apolipoprotein A‐IV (apo A‐IV) is a 46‐Kd plasma glycoprotein that may play a major role in intestinal lipid absorption. A genetic polymorphism in the apo A‐IV gene, apo A‐IV‐2, encodes a His→Gln substitution at codon 360 that alters the biological function of this apolipoprotein. As the worldwide d...

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Bibliographic Details
Published in:	Genetic epidemiology Vol. 17; no. 4; pp. 285 - 297
Main Author:	Weinberg, Richard B.
Format:	Journal Article
Language:	English
Published:	New York John Wiley & Sons, Inc 01-11-1999 Wiley-Liss
Subjects:	Alleles apolipoprotein A-IV apolipoprotein E Apolipoproteins A - genetics atherosclerosis beta-Galactosidase - metabolism Biological and medical sciences Classical genetics, quantitative genetics, hybrids Europe - epidemiology Fundamental and applied biological sciences. Psychology genetic polymorphisms Genetics of eukaryotes. Biological and molecular evolution Human Humans Iceland - epidemiology Lactase lactose intolerance Lactose Intolerance - epidemiology Lactose Intolerance - genetics milk Polymorphism, Genetic population genetics Population Surveillance Prevalence Europe Iceland Human Enzyme Lactase Apolipoprotein AIV Lipids Metabolism Persistence Allele Gene frequency Gene Glycosidases Hydrolases Adult Genetic association O-Glycosidases Polymorphism
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