Distal ileum resection totally suppresses the late pancreatic postprandial hypersecretion in conscious dogs

• Published in: Archives internationales de physiologie, de biochimie et de biophysique Vol. 101; no. 1; p. 21
• Main Authors: Huertas, J R, Martinez-Victoria, E, Ballesta, M C, Mataix, F J, Mañas, M
• Format: Journal Article
• Language: English
• Published: Belgium 01-01-1993
• Subjects: Animals; Dogs; Duodenum; Eating - physiology; Gastrins - blood; Gastrointestinal Contents; Hydrogen-Ion Concentration; Ileostomy - adverse effects; Pancreas - secretion; Secretin - blood; Time Factors; Vasoactive Intestinal Peptide - blood
• ISSN: 0778-3124
• DOI: 10.3109/13813459308998124

Exocrine pancreatic secretion and serum levels of secretin, vasoactive intestinal peptide (VIP) and gastrin within postprandial 12 hours have been studied in dogs that have undergone a partial ileum resection (last 25 cm) 4 weeks before. In these conditions the following effects were observed: 1) the flow of pancreatic juice secreted after the food intake (1-4h period) was strictly similar to the flow described in intact dogs which did not suffer that surgical manipulation but it came back to its basal value more rapidly; 2) there were no effects regarding the postprandial hormonal pattern; 3) the late pancreatic hypersecretion period that is usually observed in intact dogs within the postprandial 8-12 h period, completely disappeared. These results allow to conclude that the mechanisms inducing the late hypersecretion process that usually takes place within the postprandial 8-12 h in dogs are generated in the distal ileum.