Gender difference in red blood cell thiopurine methyltransferase activity

Gender difference in red blood cell thiopurine methyltransferase activity

High red blood cell (RBC) thiopurine methyltransferase (TPMT) activity is associated with a higher relapse rate in children with acute lymphoblastic leukaemia on 6-mercaptopurine therapy. RBC TPMT activity is subject to genetic polymorphism and inter-ethnic variation. Higher TPMT activity in male su...

Full description

Saved in:
Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation Vol. 53; no. 7; p. 747
Main Authors: Klemetsdal, B, Wist, E, Aarbakke, J
Format: Journal Article
Language:English
Published: England 1993
Subjects:
Adolescent
Adult
Erythrocytes - enzymology
Female
Humans
Male
Mercaptopurine - blood
Methyltransferases - blood
Seasons
Sex Characteristics
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High red blood cell (RBC) thiopurine methyltransferase (TPMT) activity is associated with a higher relapse rate in children with acute lymphoblastic leukaemia on 6-mercaptopurine therapy. RBC TPMT activity is subject to genetic polymorphism and inter-ethnic variation. Higher TPMT activity in male subjects has previously been reported in RBC and liver tissue, but only in non-healthy subjects. In this healthy, drug-free study group the gender difference in the RBC TPMT high activity subgroup was confirmed with 8.3% higher TPMT activity in male subjects (n = 105).
ISSN:0036-5513
DOI:10.3109/00365519309092580