First BNCT treatment of a skin melanoma in Argentina: dosimetric analysis and clinical outcome

• Published in: Applied radiation and isotopes Vol. 61; no. 5; pp. 1101 - 1105
• Main Authors: González, S.J, Bonomi, M.R, Santa Cruz, G.A, Blaumann, H.R, Larrieu, O.A.Calzetta, Menéndez, P, Rebagliati, R.Jiménez, Longhino, J, Feld, D.B, Dagrosa, M.A, Argerich, C, Castiglia, S.G, Batistoni, D.A, Liberman, S.J, Roth, B.M.C
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-11-2004
• Subjects: Argentina; BNCT; Boron - blood; Boron - pharmacokinetics; Boron Compounds - pharmacokinetics; Boron Compounds - therapeutic use; Boron Neutron Capture Therapy - methods; Clinical Protocols; Clinical trial; Female; Fructose - analogs & derivatives; Fructose - pharmacokinetics; Fructose - therapeutic use; Humans; Melanoma - metabolism; Melanoma - radiotherapy; Melanoma - secondary; Middle Aged; Radiotherapy Planning, Computer-Assisted; Skin melanomas; Skin Neoplasms - metabolism; Skin Neoplasms - radiotherapy; Skin Neoplasms - secondary; Treatment Outcome; Treatment planning; Argentina; Skin melanomas; Clinical trial; BNCT; Treatment planning
• ISSN: 0969-8043; 1872-9800
• DOI: 10.1016/j.apradiso.2004.05.060

A Phase I/II protocol for treating cutaneuos melanomas with BNCT was designed in Argentina by the Comisión Nacional de Energı́a Atómica and the medical center Instituto Roffo. The first of a cohort of thirty planned patients was treated on October 9, 2003. This article depicts the protocol-based procedure and describes the first clinical case, treatment regime and planning, patient irradiation, retrospective dosimetric analysis and clinical outcome. Considering the low acute skin toxicity and the complete response in 21 of the 25 subcutaneous melanoma nodules treated, a second irradiation was performed in a different location of the extremity of the same patient. The corresponding clinical outcome is still under evaluation.