B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis

B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis

Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that monitor disease activity or potential toxicity...

Full description

Saved in:
Bibliographic Details
Published in:Experimental neurobiology Vol. 28; no. 6; pp. 720 - 726
Main Authors: Min, Young Gi, Park, Canaria, Kwon, Young-Nam, Shin, Je-Young, Sung, Jung-Joon, Hong, Yoon-Ho
Format: Journal Article
Language:English
Published: Korea (South) The Korean Society for Brain and Neural Sciences 31-12-2019
한국뇌신경과학회
Subjects:
Original
뇌과학
Biomarkers
Flow cytometry
B-lymphocytes
Myasthenia gravis
Transcriptome
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that monitor disease activity or potential toxicity of immunosuppressants are yet to be developed. Herein, we investigated quantitative distribution of peripheral blood B cell subsets and transcriptional profiles of memory B cells (CD19+ CD27+) in several subgroups of MG patients classified according to the Myasthenia Gravis Foundation of America (MGFA) Clinical Classification. This study suggests potential immunologic B-cell markers that may guide treatment decision in future clinical settings.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1226-2560
2093-8144
DOI:10.5607/en.2019.28.6.720