Community-acquired pneumonia in the emergency department: an algorithm to facilitate diagnosis and guide chest CT scan indication

• Published in: Clinical microbiology and infection Vol. 26; no. 3; pp. 382.e1 - 382.e7
• Main Authors: Loubet, P., Tubiana, S., Claessens, Y.E., Epelboin, L., Ficko, C., Le Bel, J., Rammaert, B., Garin, N., Prendki, V., Stirnemann, J., Leport, C., Yazdanpanah, Y., Varon, E., Duval, X., Bouvard, E., Carette, M.F., Debray, M.P., Mayaud, C., Houhou, N., Benjoar, M., Blanc, F.X., Brun, A.L., Khalil, A., Lefloch, H., Naccache, J.M., Abry, A., Allo, J.C., Andre, S., Andreotti, C., Baarir, N., Bendahou, M., Benlafia, L., Bernard, J., Berthoumieu, A., Billemont, M.E., Bokobza, J., Burggraff, E., Canavaggio, P., Casalino, E., Castro, S., Choquet, C., Clément, H., Colosi, L., Dabreteau, A., Damelincourt, S., Dautheville, S., Delay, M., Delerme, S., Depierre, L., Djamouri, F., Dumas, F., Fadel, M.R.S., Feydey, A., Freund, Y., Garcia, L., Goulet, H., Hausfater, P., Ilic-Habensus, E., Josse, M.O., Kansao, J., Kieffer, Y., Lecomte, F., Lemkarane, K., Madonna, P., Meyniard, O., Mzabi, L., Pariente, D., Pernet, J., Perruche, F., Piquet, J.M., Ranerison, R., Ray, P., Renai, F., Rouff, E., Saget, D., Saïdi, K., Sauvin, G., Trabattoni, E., Trimech, N., Auger, C., Pasquet, B., Tamazirt, S., Treluyer, J.M., Tubach, F., Wang, J., Chassany, O., Misse, C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-03-2020; Elsevier for the European Society of Clinical Microbiology and Infectious Diseases
• Subjects: Chest CT scan; Community-acquired pneumonia; Diagnosis; Diagnostic methods; Emergency department; Human health and pathology; Infectious diseases; Life Sciences; Polymerase chain reaction; Respiratory viruses; Polymerase chain reaction; Emergency department; Respiratory viruses; Chest CT scan; Diagnostic methods; Community-acquired pneumonia; Diagnosis
• ISSN: 1198-743X; 1469-0691
• DOI: 10.1016/j.cmi.2019.06.026

The aim was to create and validate a community-acquired pneumonia (CAP) diagnostic algorithm to facilitate diagnosis and guide chest computed tomography (CT) scan indication in patients with CAP suspicion in Emergency Departments (ED).
We performed an analysis of CAP suspected patients enrolled in the ESCAPED study who had undergone chest CT scan and detection of respiratory pathogens through nasopharyngeal PCRs. An adjudication committee assigned the final CAP probability (reference standard). Variables associated with confirmed CAP were used to create weighted CAP diagnostic scores. We estimated the score values for which CT scans helped correctly identify CAP, therefore creating a CAP diagnosis algorithm. Algorithms were externally validated in an independent cohort of 200 patients consecutively admitted in a Swiss hospital for CAP suspicion.
Among the 319 patients included, 51% (163/319) were classified as confirmed CAP and 49% (156/319) as excluded CAP. Cough (weight = 1), chest pain (1), fever (1), positive PCR (except for rhinovirus) (1), C-reactive protein ≥50 mg/L (2) and chest X-ray parenchymal infiltrate (2) were associated with CAP. Patients with a score below 3 had a low probability of CAP (17%, 14/84), whereas those above 5 had a high probability (88%, 51/58). The algorithm (score calculation + CT scan in patients with score between 3 and 5) showed sensitivity 73% (95% CI 66–80), specificity 89% (95% CI 83–94), positive predictive value (PPV) 88% (95% CI 81–93), negative predictive value (NPV) 76% (95% CI 69–82) and area under the curve (AUC) 0.81 (95% CI 0.77–0.85). The algorithm displayed similar performance in the validation cohort (sensitivity 88% (95% CI 81–92), specificity 72% (95% CI 60–81), PPV 86% (95% CI 79–91), NPV 75% (95% CI 63–84) and AUC 0.80 (95% CI 0.73–0.87).
Our CAP diagnostic algorithm may help reduce CAP misdiagnosis and optimize the use of chest CT scan.