MUC5B Promoter Polymorphism and Development of Acute Respiratory Distress Syndrome

• Published in: American journal of respiratory and critical care medicine Vol. 198; no. 10; pp. 1342 - 1345
• Main Authors: Rogers, Angela J, Solus, Joseph F, Hunninghake, Gary M, Baron, Rebecca M, Meyer, Nuala J, Janz, David R, Schwartz, David A, May, Addison K, Lawson, William E, Blackwell, Timothy S, Ware, Lorraine B
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 15-11-2018
• Subjects: Biomarkers; Chronic obstructive pulmonary disease; Cohort Studies; Correspondence; Female; Genetic Predisposition to Disease - genetics; Genotype & phenotype; Humans; Lung diseases; Male; Medical imaging; Middle Aged; Mucin-5B - genetics; Polymorphism; Polymorphism, Single Nucleotide - genetics; Promoter Regions, Genetic - genetics; Prospective Studies; Pulmonary fibrosis; Respiratory distress syndrome; Respiratory Distress Syndrome, Adult - genetics; Sepsis; Louisiana; Tennessee; Nashville Tennessee
• ISSN: 1073-449X; 1535-4970
• DOI: 10.1164/rccm.201801-0140LE

Patients with interstitial abnormalities have been found to be at increased risk of ARDS (3). [...]we hypothesized that MUC5B risk allele carriers over age 50 would be at increased risk for the development of ARDS. Methods To test this hypothesis, we genotyped more than 2,000 subjects enrolled in the VALID (Validating Acute Lung Injury Biomarkers for Diagnosis) study, a prospective, observational cohort of critically ill patients at high risk for ARDS, enrolled at Vanderbilt University Medical Center since 2006 and approved by the Vanderbilt Institutional Review Board (4, 5). [...]although the VALID study includes more than 2,000 ICU patients, the MUC5B genotype association was limited to the 922 subjects over age 50 years, of whom 234 developed ARDS. [...]although we found no evidence that usual ARDS risk factors, such as smoking, influenced the genotype effect estimate or that genotype status affected ARDS outcomes, our power to appreciate these differences was limited. [...]given that ARDS and interstitial lung disease are both characterized by chest X-rays with infiltrates, our analysis is at risk for identifying "false-positive ARDS."