The impact of the gut microbiome on liver transplantation
PURPOSE OF REVIEWAlthough gut dysbiosis can hasten disease progression in end-stage liver disease and contribute to disease severity, morbidity and mortality, its impact during and after transplant needs further study. RECENT FINDINGSChanges in the microbiome are associated with hepatic decompensati...
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| Published in: | Current opinion in organ transplantation Vol. 26; no. 6; pp. 587 - 594 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Lippincott Williams & Wilkins
01-12-2021
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| Online Access: | Get full text |
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| Summary: | PURPOSE OF REVIEWAlthough gut dysbiosis can hasten disease progression in end-stage liver disease and contribute to disease severity, morbidity and mortality, its impact during and after transplant needs further study. RECENT FINDINGSChanges in the microbiome are associated with hepatic decompensation. Immune homeostasis is further disrupted during transplant and with immunosuppressants required after transplant. There is increasing evidence of the role of microbiota in peri and posttransplant complications. SUMMARYAlthough transplant is highly successful with acceptable survival rates, infections, rejection, disease recurrence and death remain important complications. Prognostication and interventions involving the gut microbiome could be beneficial. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 |
| ISSN: | 1087-2418 1531-7013 |
| DOI: | 10.1097/MOT.0000000000000930 |