Paraneoplastic motor neuron disease with type 1 Purkinje cell antibodies

• Published in: Muscle & nerve Vol. 21; no. 7; pp. 943 - 945
• Main Authors: Khwaja, Shamsuddin, Sripathi, Naganand, Ahmad, B.K., Lennon, Vanda A.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01-07-1998; Wiley
• Subjects: Adenocarcinoma - complications; Aged; Amyotrophic Lateral Sclerosis - etiology; Amyotrophic Lateral Sclerosis - immunology; anti-Yo; Autoantibodies - blood; Biological and medical sciences; Central Nervous System - cytology; Central Nervous System - immunology; Cerebellar Diseases - etiology; Cerebellar Diseases - immunology; Female; Humans; Immunoglobulin G - blood; Medical sciences; motor neuron disease; Motor Neurons - immunology; Motor Neurons - pathology; Nervous system involvement in other diseases. Miscellaneous; Neurology; ovarian cancer; Ovarian Neoplasms - complications; paraneoplastic; Paraneoplastic Syndromes - complications; Paraneoplastic Syndromes - immunology; Purkinje Cells - immunology; type 1 Purkinje cell antibodies; Case study; Human; Nervous system diseases; Antibody; Central nervous system disease; Purkinje neuron; Motor neuron disease; Degenerative disease; Paraneoplastic syndrome; Serology; Spinal cord disease
• ISSN: 0148-639X; 1097-4598
• DOI: 10.1002/(SICI)1097-4598(199807)21:7<943::AID-MUS14>3.0.CO;2-R

Autoimmune serological testing is a useful aid for identifying a paraneoplastic basis for sporadic motor neuron disease. A 67‐year‐old woman with ovarian carcinoma presented with progressive weakness. Neurological examination was suggestive of motor neuron disease with signs of upper motor neuron disorder. Electromyography revealed severe motor neuronopathy of the upper extremities. Characteristic type 1 Purkinje cell antibodies (anti‐Yo antibody) was detected in the serum diluted at 1:61,400. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:943–945, 1998.