Current Applications of Suzuki–Miyaura Coupling Reaction in The Total Synthesis of Natural Products: An update

• Published in: Applied organometallic chemistry Vol. 32; no. 3
• Main Authors: Taheri Kal Koshvandi, Afsaneh, Heravi, Majid M., Momeni, Tayebeh
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01-03-2018
• Subjects: carbon‐carbon bond formation; Chemical synthesis; Chemistry; Corporate profiles; Coupling; Natural products; Palladium; Suzuki‐Miyaura reaction; Total synthesis
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.4210

Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis of natural products. We underscored these achievements in a report published in Tetrahedron up to 2012. Since then, there has been tremendous growth in this field and numerous articles have been published after 2012. In this review, we tried to go insight and highlight the current developments in the applications of SMCR as a key and strategic step (steps) in the total synthesis of biologically active natural products accomplished and reported from 2012 till date.
Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis of natural products. SMCR is an organic reaction, classified as an important cross coupling reaction, where the coupling partners are an appropriate boronic acid and a suitable organohalide, catalyzed by a palladium(0) complex. In this review, we try to underscore the current developments in the applications of SMCR as a key and strategic step (steps) in the total synthesis of natural products, published from 2012 till date.