Autoinflammatory associated vasculitis

• Published in: Seminars in arthritis and rheumatism Vol. 46; no. 3; pp. 367 - 371
• Main Authors: Ginsberg, Shira, MD, Rosner, Itzhak, MD, Rozenbaum, Michel, MD, Slobodin, Gleb, MD, Zilber, Karina, MD, Boulman, Nina, MD, Kaly, Lisa, MD, Awisat, Abid, MD, Jiries, Nizar, MD, Beyar-Katz, Ofrat, MD, Rimar, Doron, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-12-2016
• Subjects: Adult; Antibodies, Anticardiolipin - immunology; Antibodies, Antineutrophil Cytoplasmic - immunology; Antibodies, Monoclonal - therapeutic use; Antirheumatic Agents - therapeutic use; Autoinflammatory diseases; Cryopyrin-Associated Periodic Syndromes - complications; Cryopyrin-Associated Periodic Syndromes - drug therapy; Cryopyrin-Associated Periodic Syndromes - immunology; Cryopyrin-Associated Periodic Syndromes - physiopathology; Female; Humans; Interleukin 1 Receptor Antagonist Protein - therapeutic use; Leukocytoclastic vasculitis; Male; Mevalonate Kinase Deficiency - complications; Mevalonate Kinase Deficiency - drug therapy; Mevalonate Kinase Deficiency - immunology; Mevalonate Kinase Deficiency - physiopathology; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; Phosphotransferases (Alcohol Group Acceptor) - genetics; Rheumatology; Vasculitis, Leukocytoclastic, Cutaneous - complications; Vasculitis, Leukocytoclastic, Cutaneous - drug therapy; Vasculitis, Leukocytoclastic, Cutaneous - pathology; Vasculitis, Leukocytoclastic, Cutaneous - physiopathology; Young Adult; Leukocytoclastic vasculitis; Autoinflammatory diseases
• ISSN: 0049-0172; 1532-866X
• DOI: 10.1016/j.semarthrit.2016.07.007

Abstract Autoinflammatory diseases are characterized by recurrent episodes of fever and localized or systemic inflammation and are caused by monogenic defects of innate immunity. The skin is commonly involved with various manifestations including erysipelas like rash and urticaria. Although vasculitis has been described in many autoinflammatory diseases, it has not been recognized as a characteristic feature of these diseases and autoinflammatory diseases are not listed as an etiology for vasculitis associated with a systemic disease in the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. We describe herein 3 patients with different autoinflammatory diseases in whom leukocytoclastic vasculitis was one of the major and presenting symptoms. A review of the vast evidence in the literature for vasculitis in the spectrum of autoinflammatory diseases and a suggested pathophysiology is presented. We suggest the term autoinflammatory associated vasculitis to describe vasculitis associated with autoinflammatory diseases. Autoinflammatory diseases should be considered within the differential diagnosis of vasculitis.