Modality specificity in the cerebro-cerebellar neurocircuitry during working memory

• Published in: Behavioural brain research Vol. 305; pp. 164 - 173
• Main Authors: Ng, H.B. Tommy, Kao, K.-L. Cathy, Chan, Y.C., Chew, Effie, Chuang, K.H., Chen, S.H. Annabel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-05-2016
• Subjects: Adult; Brain Mapping; Cerebellum; Cerebellum - diagnostic imaging; Cerebellum - physiology; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiology; Cerebro-cerebellar; Female; Functional Laterality - physiology; Functional magnetic resonance imaging; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Memory, Short-Term - physiology; Neural Pathways - diagnostic imaging; Neural Pathways - physiology; Oxygen; Pattern Recognition, Visual; Photic Stimulation; Psychomotor Performance; Verbal Learning - physiology; Verbal working memory; Visual working memory; Young Adult; Cerebellum; Functional magnetic resonance imaging; Visual working memory; Verbal working memory; Cerebro-cerebellar
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2016.02.027

•We examined hemispheric lateralization patterns in working memory.•Left lateralized IFG and IPL were activated during verbal working memory.•Right lateralized cerebellar lobular VI and VIII were also activated in verbal working memory.•A left-cortical right-cerebellar network underlies verbal working memory.•No evidence for a right-cortical left-cerebellar network in visual working memory.
Previous studies have suggested cerebro-cerebellar circuitry in working memory. The present fMRI study aims to distinguish differential cerebro-cerebellar activation patterns in verbal and visual working memory, and employs a quantitative analysis to deterimine lateralization of the activation patterns observed. Consistent with Chen and Desmond (2005a,b) predictions, verbal working memory activated a cerebro-cerebellar circuitry that comprised left-lateralized language-related brain regions including the inferior frontal and posterior parietal areas, and subcortically, right-lateralized superior (lobule VI) and inferior cerebellar (lobule VIIIA/VIIB) areas. In contrast, a distributed network of bilateral inferior frontal and inferior temporal areas, and bilateral superior (lobule VI) and inferior (lobule VIIB) cerebellar areas, was recruited during visual working memory. Results of the study verified that a distinct cross cerebro-cerebellar circuitry underlies verbal working memory. However, a neural circuitry involving specialized brain areas in bilateral neocortical and bilateral cerebellar hemispheres subserving visual working memory is observed. Findings are discussed in the light of current models of working memory and data from related neuroimaging studies.