Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion

A 36-year-old Caucasian male presented with adult T-cell leukemia/lymphoma (ATL). HTLV-1 contamination was attributed to a neonatal exchange transfusion. Remission was achieved but 11 years later he presented with symptoms suggesting ATL relapse. Molecular studies of T-cell clonality and virus integ...

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Bibliographic Details
Published in:	International journal of hematology Vol. 105; no. 6; pp. 859 - 862
Main Authors:	Oksenhendler, Eric, Turpin, Jocelyn, Lhote, Raphael, Cassar, Olivier, Cayuela, Jean-Michel, Fieschi, Claire, Galicier, Lionel, Meignin, Veronique, Bangham, Charles, Gessain, Antoine
Format:	Journal Article
Language:	English
Published:	Tokyo Springer Japan 01-06-2017 Springer Nature B.V Springer Verlag
Subjects:	Adult Antineoplastic Combined Chemotherapy Protocols Antineoplastic Combined Chemotherapy Protocols - administration & dosage Case Report Exchange Transfusion, Whole Blood Female Health risks Hematology Human T-lymphotropic virus 1 Humans Immunology Infections Leukemia Leukemia-Lymphoma, Adult T-Cell Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemia-Lymphoma, Adult T-Cell - etiology Life Sciences Lymphocytes T Lymphoma Male Medicine Medicine & Public Health Newborn babies Oncology Pregnancy Remission Induction Adult T-cell leukemia/lymphoma HTLV-1 Transfusion
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Summary:	A 36-year-old Caucasian male presented with adult T-cell leukemia/lymphoma (ATL). HTLV-1 contamination was attributed to a neonatal exchange transfusion. Remission was achieved but 11 years later he presented with symptoms suggesting ATL relapse. Molecular studies of T-cell clonality and virus integration sites revealed a clonal disease, distinct from the first tumor.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0925-5710 1865-3774 0925-5710
DOI:	10.1007/s12185-016-2174-0