Dysgerminoma and gonadoblastoma in the course of Swyer syndrome

• Published in: Polish journal of pathology Vol. 67; no. 4; pp. 411 - 414
• Main Authors: Milewicz, Tomasz, Mrozińska, Sandra, Szczepański, Wojciech, Białas, Magdalena, Kiałka, Marta, Doroszewska, Katarzyna, Kabzińska-Turek, Monika, Wojtyś, Andrzej, Ludwin, Artur, Chmura, Łukasz
• Format: Journal Article
• Language: English
• Published: Poland Termedia Publishing House 2016
• Subjects: Abdomen; Adolescent; Age; Amenorrhea; Bladder; Chemotherapy; dysgerminoma; Dysgerminoma - genetics; Dysgerminoma - pathology; Endocrinology; Female; Gonadal Dysgenesis, 46,XY - complications; gonadoblastoma; Gonadoblastoma - genetics; Gonadoblastoma - pathology; Gonads - pathology; Gynecology; Hormone replacement therapy; Humans; Laboratories; Lymphatic system; Metastasis; Mutation; Ovarian cancer; Patients; Surgery; Swyer syndrome; Tumors; Uterus; Vagina; Baltimore Maryland; Swyer syndrome; dysgerminoma; gonadoblastoma
• ISSN: 1233-9687; 2084-9869
• DOI: 10.5114/pjp.2016.65876

We present a case of a woman with primary amenorrhea. Ultrasound imaging showed a uterus of normal size but bands of connective tissues at the site of ovaries. A genetic test was done which revealed the XY karyotype. Swyer syndrome was diagnosed. The patient did not report for the follow-up visits. Three years later, the woman reported back because of increasing abdominal circumference. The patient underwent an operation. Radical hysterectomy was performed. Histopathological examination showed dysgerminoma and gonadoblastoma on the left gonad and dysgerminoma on the right one. This case report presents the natural history of Swyer syndrome.